Hello Sue,
The problem is your from address for the ticket. If you want your ticket to receive the reply, you must reply to the email address your ticket emails come in at, and keep the subject line the same.
When WHMCS pop's or pipes this message in, it will auto post to the ticket and send the response to the client.
I am not sure what is causing it but I am having the same issue too with two of our WHMCS systems. They are both on different servers and connect to two different mailservers. However with both of them having nothing in common, they are having the same problem. Piping is working correctly on some of the email addresses but not all.